NJCA
  • Users Online: 236
  • Print this page
  • Email this page
  • Email this page
  • Facebook
  • Twitter
ORIGINAL ARTICLE
Year : 2022  |  Volume : 11  |  Issue : 1  |  Page : 42-48

Fetal gall bladder development: A histo-morphometric study


1 Assistant Professor, Department of Anatomy, Soban Singh Jeena Government Institute of Medical Sciences and Research, Almora, Uttarakhand, India
2 Assistant Professor, Department of Pathology, Government Medical College, Haldwani, Uttarakhand, India
3 Professor and Head, Department of Anatomy, Government Medical College, Haldwani, Uttarakhand, India
4 Head, Department of Anatomy, Government Medical College, Haldwani, Uttarakhand, India

Correspondence Address:
Anamika Jaiswal
Department of Anatomy, Soban Singh Jeena Government Institute of Medical Sciences and Research, Almora, Uttarakhand
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/NJCA.NJCA_89_21

Rights and Permissions

Background: The gall bladder development in fetal life is complex and starts as early as the 4th week of gestation; the abnormal development of the gall bladder is associated with various congenital abnormalities. The objective of the present study was to study fetal gall bladder development in relation to gestational age (GA) among fetuses. Methodology: In a cross-sectional observational study of 29 fetuses, the gall bladder parameters and histological changes are evaluated at different gestational age. The fetus was categorized based on GA into three categories of <20 weeks, 21–30 weeks, and 31 weeks and above. After dissection of the abdomen, the shape and location of the gall bladder were observed. The relationship of gall bladder with liver was observed. The gall bladder length (GBL) and gall bladder width (GBW) were measured. The histogenesis of the gall bladder was observed among all fetuses and developmental changes were noted. Results: The study included 29 fetuses, 14 males and 15 females. The first, second, and third groups comprised 5, 14, and 10 fetuses. The GA ranged from 13 to 35 weeks. The mean crown-rump length (CRL) of the fetuses was 19.34 ± 6.32 cm. The mean GBL was 2.06 ± 0.83 cm and the mean GBW was 0.77 ± 0.32 cm. The GBL and GBW increased with CRL, GA, and weight. The strong positive correlation was observed between GBL, GBW with GA and CRL. On microscopy, among the first group, fetal gall bladder at 13 weeks showed solid structure with obliterated lumen and area of early canalization. The muscular layer initially was very thin and comprised only few haphazardly arranged muscle fiber in the first group, the thickness was found to be more in the second group and a well-formed adult-like muscular layer was found in the third group. The loose connective tiisue, the outer most layer was pronounced in the third group. Conclusion: The fetal gall bladder parameters show linear increase with GA and CRL. The location, size, and relation of the fundus with margin of gall bladder in fetus undergo changes with the development of the fetus. The fetal gall bladder undergoes marked histological changes during development.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed351    
    Printed12    
    Emailed0    
    PDF Downloaded37    
    Comments [Add]    

Recommend this journal